The 7 Best At-Home STD Tests in 2025: What to Expect, How They Work, and How Much They Cost

At-home STD tests are changing the way people take care of their sexual health. No more awkward clinic visits or waiting weeks for results; today’s best at-home kits offer professional-grade testing from the privacy of your home.

But which one should you trust with your health?

How We Ranked These Tests

We evaluated dozens of at-home STD testing options and ranked the top 7 based on:

• What each test screens for: Does it test for the most common STIs?
• Ease of use: Is the collection process simple and clearly explained?
• Result turnaround time: How long do you wait for results?
• Cost: What’s the base price, and are there insurance or FSA/HSA options?
• Privacy: Is the test discreet? Is your data protected?
• User reviews: We analyzed verified reviews from Trustpilot, Amazon, and company websites to understand real-world user experiences.

The Top 7 At-Home STD Tests of 2025

1. LetsGetChecked: Best Overall Home STD Test

LetsGetChecked offers a complete, CLIA-certified test panel and nurse support, all in a discreet package.

What it tests for: Chlamydia, gonorrhea, syphilis, HIV, trichomoniasis, bacterial vaginosis (BV), mycoplasma, and ureaplasma

How it works: You collect a urine sample and a finger-prick blood sample at home. The kit includes everything you need: lancets, collection tubes, prepaid return mailer, and detailed instructions. Once the lab receives your sample, results are ready in 2–5 business days.

What users say: Thousands of 5-star reviews praise the clear instructions and responsive nurse support. Trustpilot rating: 4.6/5.

What makes it stand out: If you test positive, a nurse will call to walk you through your results. They can prescribe treatment in many cases, and help you plan next steps. Ideal for routine screening or first-timers.

Cost: ~$149 (HSA/FSA accepted)

Insurance: Not billed to insurance

Customer Feedback: 

• "They were very timely with giving my results" - Ethan Dolin, US (June 2025)
• "Results were amazingly fast, and I was able to get good information quickly from your clinician" - Janice Dietrich, US (June 2025)

2.  Everlywell STD Test: Fastest Results

If speed is your top priority, Everlywell’s STD panel delivers fast lab results with strong user-friendly features.

What it tests for: Chlamydia, gonorrhea, trichomoniasis, syphilis, hepatitis C

How it works: Collect a finger-prick blood sample and urine specimen. Mail to Everlywell’s partner lab using the prepaid label. You’ll get results within 1–2 business days of lab receipt.

What users say: Highly rated for fast turnaround and intuitive packaging. Some users report false positives or invalid samples. Trustpilot rating: 3.6/5.

What makes it stand out: You’ll get a secure online report and optional physician follow-up. The Everlywell app adds a polished digital experience.

Cost: ~$149 (often discounted to ~$135)

Insurance: Not accepted; FSA/HSA eligible

Customer Feedback:

• “Heed the warnings of others! I wish I had read the reviews before making a purchase. Customer service is horrible.” - Em, US (July 2025)
• “The instructions were easy and it was easy to register my kit online. The only downside for me was that I would have liked the results faster. It took 8 business days to get results from the time I mailed them.” - Mary M, US (April 2025)

3. myLAB Box Total Box: Most Comprehensive Test Panel

For those who want the most thorough screening at home, myLAB Box’s 14-panel kit is unmatched.

What it tests for: Chlamydia and gonorrhea (3-site: genital, oral, rectal), HIV, HSV-2, syphilis, trich, hepatitis C, mycoplasma, genital HPV (optional)

How it works: You’ll collect a urine sample, blood sample, and up to three swabs. Prepaid return shipping is included. Results are typically available online within 5 business days.

What users say: Users appreciate the comprehensive coverage but some reported slower lab processing or confusion with multi-site swabbing. Trustpilot rating: 2.5/5.

What makes it stand out: It’s the only kit that covers three-site testing and includes less commonly tested STIs like mycoplasma. Includes a free telehealth consultation if your test comes back positive.

Cost: $369 (14-panel kit)

Insurance: Not accepted; FSA/HSA eligible

Customer Feedback:

• “The kits are expensive, but there are usually coupons for significant savings so do a little research before buying. Very convenient and easy to use in your own home.” - Eric Carter, US (May 2025)
• “The testing is easy, the results are fast, and the customer service personnel are always responsive to questions.” - J.D., US (March 2025)

4. OraQuick In-Home HIV Test: Best for Immediate Results

The OraQuick FDA-approved home HIV test is your fastest option, no mail-in required.

What it tests for: HIV-1 and HIV-2 antibodies

How it works: Swab your gums, place the test stick in the developer vial, and read the result window in 20–40 minutes.

What users say: OraQuick earns top reviews for speed and privacy. Some users report anxiety about interpreting the result correctly. Amazon rating: 4.5/5.

What makes it stand out: No shipping, no waiting, no data sharing. Results stay entirely in your hands.

Cost: ~$39

Insurance: Available OTC; not reimbursed unless medically ordered

Important note: May not detect very recent infections (window period ~3 months)

Customer Feedback:

• “This test kit is easy to use and provides quick, confidential results. It’s a great option for anyone wanting privacy and convenience. The instructions are clear, and the result accuracy is reassuring.” - Keyanna, US (June 2025)
• "I used this test kit for years. However, I received a positive oral exam this last time and went into a panic. I had blood work done that proved it was a false positive" - Peco, US (March 2023)

5. Nurx Full Control Kit: Best for Insurance Use

Nurx brings telehealth into the picture: testing, treatment, and prescription all from home.

What it tests for: HIV, syphilis, chlamydia, gonorrhea, hepatitis C

How it works: Complete a health questionnaire, receive a kit, and collect samples (urine, blood, swabs). Results are posted in about 7 business days. Telehealth support is built-in.

What users say: Mixed reviews. Some customers love the bundled experience and insurance acceptance, while others report billing issues or long wait times. Trustpilot rating: 2.6/5.

What makes it stand out: The only at-home test provider on this list that works with insurance. If you're uninsured, the flat-rate kit is still competitive.

Cost: ~$44.50 with insurance; ~$220 without

Insurance: Accepted; fees vary

Customer Feedback:

• “Overall I definitely recommend Nurx! They make the process super easy, on my own time, and always answer any questions I have.” - Patient, US (July 2024)
• "TLDR: Nurx takes a month to get your results... All said and done, you're talking like a month-long process" - LJ, US (January 2025)

6. First To Know Syphilis Test: Best Rapid Syphilis Option

Recently released on the market, First To Know  is the only FDA-approved rapid syphilis test for home use.

What it tests for: Syphilis antibodies (screening)

How it works: Prick your finger and apply a blood drop to the test cassette. Results are ready in 15 minutes.

What users say: Still new on the market, but early reviews highlight speed, simplicity, and peace of mind.

What makes it stand out: Ideal for high-risk individuals or those wanting quick, private testing between partner changes.

Cost: ~$30

Insurance: Not accepted

Customer Feedback:

• “The test worked well and it was nice to do it right away and not have to wait a week for results.” - Big Chief, US (April 2025)
• “I'm not a novice at these kinds of tests and so I followed the procedure to the letter and got an inconclusive result. Ordered two kits and used the 2nd one with the same results. Very disappointed in this product.” - Amazon Customer, US (November 2024)

Cost Comparison Snapshot

Final Thoughts

At-home STD tests are a fast, private way to take control of your health. They're best for:

• People who want routine screening
• Anyone recently exposed to an STD
• Those without easy access to clinics

Each test has trade-offs: Rapid kits like OraQuick offer speed, while lab-based kits offer accuracy and comprehensive results. No matter which you choose, remember that all positive results should be confirmed with a provider, and follow-up care is essential.

Want complete privacy and lab-grade testing without leaving home? Start with LetsGetChecked or myLAB Box. Have insurance? Nurx might be the most affordable route.

Need local testing options instead? Visit LabCafe to schedule a test at a nearby lab and take control of your health today.

Frequently Asked Questions (FAQ)

Are at-home STD tests accurate?

Yes. Most at-home STD tests use the same lab methods as clinics. Tests processed in CLIA-certified labs or approved by the FDA (like OraQuick and First To Know) meet clinical standards for accuracy. That said, all positive results should be confirmed with a provider.

Do I need to collect blood for every test?

Not always. Many tests (like chlamydia and gonorrhea) only require a urine sample or swab. Others, like syphilis or HIV, typically require a small finger-prick blood sample. OraQuick is the only one with no blood collection at all.

How long after exposure should I get tested?

It depends on the infection. HIV and syphilis antibodies may take 3–6 weeks to show up. Chlamydia and gonorrhea may show up in 1–2 weeks. If you’re unsure when to test, consult with a healthcare provider or use a test that includes telehealth support.

Will insurance cover these tests?

Most home test services do not bill insurance directly. However, some—like Nurx—do accept insurance. Others may be eligible for FSA or HSA reimbursement.

Will anyone else know I ordered a test?

No. These services use discreet packaging and secure digital portals. If you don’t use insurance, your testing won't appear on insurance records.

Can I get treated if I test positive?

Yes. Services like LetsGetChecked and Nurx offer medical support and can prescribe treatment for many common infections. If your provider doesn’t offer treatment directly, they’ll advise you on next steps.